Outline
DOI: 10.1039/d6cb00150e ISSN: 2633-0679
Mechanism-based inhibition of zinc-dependent histone deacetylases
David W. ChristiansonDifluoromethyl-1,3,4-oxadiazoles are highly selective, mechanism-based inhibitors of histone deacetylase 6. The electrophilic CN bond of the heterocycle undergoes nucleophilic attack by zinc-bound water to yield a zinc-bound acylhydrazide anion.
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