DOI: 10.1039/d6bm00713a ISSN: 2047-4830
Mechanical stress-driven conformational compaction of polydeoxyribonucleotide for enhanced transdermal regenerative therapy
Saetbyeol Jeon, Jung Im Lee, Sung Bo Shim, Chul Hwan Kim, Taek Jin Oh, Marta Gonçalves, Jin Woong KimChemically unmodified PDRN undergoes mechanical stress-driven conformational compaction, enhancing transdermal penetration, cellular uptake, and regenerative efficacy while preserving native receptor-mediated bioactivity.