DOI: 10.1177/23259582261436955 ISSN: 2325-9582

MASLD in PLWH on ART: Predominance of Metabolic Risk Factors and Insights From Novel Biomarkers—A Cross-Sectional Study in Wrocław, Poland

Michał Biały, Małgorzata Inglot
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Background

MASLD (NAFLD) is the most common chronic hepatopathy and has a rising prevalence in PLWH, with etiological factors being interplay of HIV-specific with general ones.

Methods

We conducted a cross-sectional study ( n  = 93). Patients were assessed in an outpatient clinic in Poland (April-October 2021) using clinical, metabolic data, irisin, CK-18, adiponectin, and leptin. Noninvasive formulas were used to assess the MASLD risk biochemically.

Results

No statistically relevant differences in MASLD-related scores among different ART regimens were found, with weak correlations were found between CD4 count and NAFLD-LFS ( R  < .3), and ART duration with non-HDL-C ( R  = −.22) and NFS ( R  = .23). Lifetime weight amplitude showed relationship with biochemical MASLD-related formulas and hepatitis ( P  = .037); among the biomarkers, leptin exhibited several correlations, strongest with HSI ( R  = .56) and BMI ( R  = .53).

Conclusions

MASLD corresponded more with general than with ART-related factors. Leptin may value when evaluating MASLD risk.

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