Mannose Ameliorates Radiation-Induced Intestinal Injury in Mice via Preventing Mitochondrial Dysfunction
Yanqing Liu, Renjun Peng, Yiying Zhang, Jing Dai, Suhe Dong, Huijie Yu, Sinian Wang, Zhongmin Chen, Qisheng Jiang, Wei Li, Yining Yue, Jianan Wang, Jie Xu, Zhongtang Li, Fengsheng LiAims:
Radiation-induced intestinal injury (RIII) severely compromises the quality of life in patients undergoing abdominal/pelvic radiotherapy and may necessitate treatment discontinuation. To date, there is no approved agent for the prevention or treatment of RIII. This study aims to clarify the protective effects of mannose on RIII and elucidate its mechanisms of action, in order to identify new safe and effective therapeutic agents and potential therapeutic targets for the prevention and treatment of RIII.
Results:
Here, we report that intraperitoneal administration of mannose, a natural bioactive monosaccharide, at 24, 12, and 2 h prior to lethal irradiation increased the survival rate of mice from 0% to 50%. Specifically, mannose pretreatment significantly blocked crypt cell apoptosis, preserved epithelial barrier integrity, attenuated intestinal inflammation, and enhanced crypt regeneration. Additionally, mannose treatment enhanced the survival of intestinal stem cells both
Conclusion and Innovation:
Given its low toxicity and wide availability, our findings suggest that mannose represents a promising protective strategy for RIII.