Management of primary hypothyroidism-associated hyperprolactinemia through Pradhamana Nasya Karma and Jalakumbhi Kshara: A case series
Amisha. P. Patel, Kalapi B. PatelAbstract
BACKGROUND:
Thyroid hormones and prolactin are intricately linked through shared regulatory pathways. In primary hypothyroidism, elevated thyrotropin-releasing hormone levels can induce hyperplasia of thyrotroph and lactotroph cells, potentially leading to pituitary gland enlargement and concurrent hyperprolactinemia. The association between thyroid dysfunction and prolactin imbalance is well established across various clinical conditions.
MATERIALS AND METHODS:
This case series investigates four patients diagnosed with primary hypothyroidism and comorbid hyperprolactinemia. The therapeutic intervention consisted of two sessions of
RESULTS:
After 4 weeks of treatment, all four patients demonstrated improvement in thyroid function parameters. Serum TSH levels decreased from 8.67 to 16.87 µIU/mL at baseline to 3.50–7.25 µIU/mL post-treatment, while free T4 levels increased from 0.5–0.7 ng/dL to 1.0–1.2 ng/dL. Serum prolactin levels decreased in three patients and remained unchanged in one patient. Objective clinical assessment showed reductions in symptom scores for diminished sweating, dry skin, cold intolerance, constipation, hoarseness of voice, coarse skin, cold skin, puffiness, slowed movements, and pulse rate abnormalities across the cases. The four cases studied showed significant improvements in the parameters assessed using the Billewicz Diagnostic Index.
CONCLUSION:
The combined administration of