Outline
DOI: 10.1084/jem.20240088 ISSN: 0022-1007
Macro-clusters: CD301b+ DCs prime Th2 responses
Hanna Abberger, Joanna R. Groom- Immunology
- Immunology and Allergy
In this issue of JEM, Lyons-Cohen et al. (https://doi.org/10.1084/jem.20231282) reveal that lymph node macro-clusters provide a spatial niche where CD301b+ cDC2s and CD4+ T cells interact. These integrin-mediated cellular hubs promote enhanced co-stimulation and cytokine signaling to drive Th2 differentiation.
More from our Archive
- DOI: 10.1128/jvi.00242-24 2024Conditional splicing system for tight control of viral overlapping genesQing Yang, Jinlin Wang, Zhiwei Chen
- DOI: 10.1084/jem.20221983 2024VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke modelLigia Simoes Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renee El Kamouh, Seyoung Lee, Basavaraju G. Sanganahalli, Myriam Spajer, Shenqi Zhang, Sungwoon Lee, Maxime Parent, Yuechuan Xue, Mario Skarica, Xiangyun Yin, Justine Guegan, Kevin Boyé, Felipe Saceanu Leser, Laurent Jacob, Mathilde Poulet, Mingfeng Li, Xiodan Liu, Sofia E. Velazquez, Ruchith Singhabahu, Mark E. Robinson, Michael H. Askenase, Artem Osherov, Nenad Sestan, Jiangbing Zhou, Kari Alitalo, Eric Song, Anne Eichmann, Lauren H. Sansing, Helene Benveniste, Fahmeed Hyder, Jean-Leon Thomas
- DOI: 10.1084/jem.20231282 2024Site-specific regulation of Th2 differentiation within lymph node microenvironmentsMiranda R. Lyons-Cohen, Elya A. Shamskhou, Michael Y. Gerner
- DOI: 10.1093/jleuko/qiae046 2024In-depth human immune cellular profiling from newborn to frailWangchun Li, Hangyu Liu, Lijuan Gao, Yang Hu, Anna Zhang, Wenfeng Li, Guolong Liu, Weibin Bai, Yudai Xu, Chanchan Xiao, Jieping Deng, Wen Lei, Guobing Chen
- DOI: 10.1155/2024/9382107 2024Autoreactive Antibodies Associated with Castleman Disease TriadJacqueline A. Turner, Ali Hakimi, Hannah Lee, Jeffrey T. Schowinsky, Jeffrey M. Sippel, Bradford J. Siegele, Raul M. Torres, William A. Robinson
- DOI: 10.1139/cjm-2023-0188 2024Biological and Genomic Characteristics of Three Novel Bacteriophages and a Phage-Plasmid of Klebsiella pneumoniaeAylin Uskudar Guclu, Sezin Unlu, Hanife Salih Doğan, Suleyman Yalcin, Ahmet Basustaoglu
- DOI: 10.1182/blood.2023023549 2024Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia miceAsim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez-Calderon, Elisa Rojas Palato, Margaret L. MacMillan, John E Wagner, Leslie S. Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M. Olson, Bruce R. Blazar
- DOI: 10.1182/blood.2023021287 2024Long noncoding RNA GATA2AS influences human erythropoiesis by transcription factor and chromatin landscape regulationGuoyou Liu, Juhyun Kim, Nicole Han Nguyen, Lecong Zhou, Ann Dean
- DOI: 10.1177/23259582241236260 2024The Effect of a Group-Based Mindfulness and Acceptance Training on Psychological Flexibility and Adherence to Antiretroviral Therapy Among Adolescents in Uganda: An Open-Label Randomized TrialKhamisi Musanje, Moses R. Kamya, Rosco Kasujja, Wouter Vanderplasschen, Deborah L. Sinclair, Martin M. Baluku, Raymond F. Odokonyero, Charles P. Namisi, John Mukisa, Ross G. White, Carol S. Camlin
- DOI: 10.1155/2024/5722548 2024Clinical and Genetic Spectrum of Nine Cases of NLRP3-Associated Autoinflammatory Disease (NLRP3-AID) and Identification of One Novel NLRP3 Mutation by Genetic Variation AnalysesYaoyao Shangguan, Xingru Ding, Le Ma, Yi-Xin Cai, Shulei Xiang, Xiu-Feng Huang, Yunyan Shen, Hai-Guo Yu, Wenjie Zheng