DOI: 10.1039/d6ra03733j ISSN: 2046-2069
Machine learning-based molecular detection using dark-field observation of two different nanoparticles
Yuki Yano, Gen Hirao, Ryosuke Izumi, Yu Muto, Misato Yasuoka, Tsuyoshi Asahi, Takuo Tanaka, Mizuo Maeda, Tamotsu ZakoWe developed a method to detect a target inducing heterodimer formation of heterogeneous nanoparticles using dark-field microscopy. Heterodimer was identified by classification of observed spots at the single cluster level using machine learning.