M0K0 M1K1 Grading System for Oral Squamous Cell Carcinoma - A Retrospective Study
Srikant Natarajan, K.P Nandita, Karen Boaz, Amitha Lewis, Nidhi Manaktala, Shweta PaiAbstract
Introduction:
The Bryne’s grading system for invasive tumour fronts is a widely used method for predicting oral squamous cell carcinoma (OSCC) outcomes. Tumour cell maturation and proliferation are key factors in malignancy. This study aims to assess keratinisation and mitosis, correlating them with prognostic factors like margin status, lymph node involvement, recurrence, and survival.
Materials and Methods:
Haematoxylin and Eosin-stained sections from 70 OSCC cases were retrieved, and Bryne’s Invasive Tumour Front grading was applied. Ten high-power fields at the invasive front were assessed for keratinisation and mitosis to calculate the maturation–proliferation (MP) index. The MP index was correlated with prognostic factors and compared using the Mann–Whitney U test.
Results:
Higher grades in both Bryne’s and modified Bryne’s grading correlated with involved margins, lymph nodes, recurrence, and death. Free surgical margins showed dense lymphocytic infiltrates, indicating an immune response.
Conclusion:
The MP index identifies high-proliferative cells, assisting in predicting OSCC progression and metastasis.
Clinical Significance:
Analysing maturation and proliferation provides critical insights, supporting informed decisions in OSCC treatment.