Outline
DOI: 10.1083/jcb.202606052 ISSN: 0021-9525
Lysosomal acidification through membrane contacts with mitochondria
Zhiqi Tian, Yujie Sun, Jiajie DiaoRecent work from two independent studies has uncovered mitochondria as a previously unrecognized proton source driving lysosomal acidification. In this Viewpoint, we summarize these findings, examine the associated proteins and functional mechanisms, and discuss their relevance to disease.
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