LY07 Evaluation of a virtual multicentric interdisciplinary tumour board for cutaneous lymphoma

Abstract

Cutaneous T-cell lymphomas (CTCLs) are a rare, challenging and heterogeneous group of lymphoma diseases requiring complex interdisciplinary treatment decisions. To improve diagnostics and clinical decision making we established a virtual multidisciplinary cutaneous lymphoma tumour board multidisciplinary team (MDT). Here, we present data of the first longitudinal evaluation of the MDT focusing on performance, acceptance and its impact on diagnostics and treatment decisions. We analysed cases presented and discussed in the MDT since its initiation in 2022. In addition, a questionnaire was sent to all participating centres to evaluate overall satisfaction, as well as therapeutic and diagnostic recommendations. In total 121 cases from 26 centres in Germany were included in our evaluation. The most frequent diagnosis was mycosis fungoides, including its subtypes (47.2%), followed by Sézary syndrome (16.5%). The majority of patients were male (57.5%). The median age at presentation was 64 years (interquartile range 52.3–72). At the time of presentation, most patients had already received skin-directed therapies (81.1%), systemic therapies (73%) and/or extracorporeal photopheresis (ECP 36.1%). In 14.9% of cases further imaging was recommended, while additional diagnostic procedures were suggested in 52.1%, most commonly skin biopsies (25.2%) and molecular pathology analyses (13.5%). In 15.0% of cases, the therapy proposed at registration was confirmed without modification, whereas an adjustment of the previous therapy was recommended in 85.0% of cases. The five most frequently recommended therapies were total-skin electron beam therapy (10.9%), allogeneic haematopoietic stem cell transplantation (9.9%), systemic treatment with brentuximab vedotin (8.3%) or interferon alfa-2a (7.9%), and extracorporeal photopheresis (7.6%). In the majority of cases presented at the MDT, adjustments to the initially suggested therapy were recommended. Moreover, extended diagnostic procedures and additional imaging were frequently advised. Data derived from evaluation forms are currently being processed and the data will be presented at the conference.