DOI: 10.1001/jamaoncol.2026.4014 ISSN: 2374-2437

Long-Term Outcomes of De-Escalated 30-Gy Elective Irradiation in HPV-Associated Oropharyngeal Cancer

Amir H. Safavi, E. Christopher Dee, C. Jillian Tsai, Yingzhi Wu, Sean M. McBride, Daphna Y. Gelblum, Yao Yu, Linda C. Chen, Kaveh Zakeri, Achraf Shamseddine, Jung J. Kang, Hannah Joy, Allison Sheih, Diana Roth O’Brien, Jennifer R. Cracchiolo, Richard J. Wong, Marc A. Cohen, Ian Ganly, Lara A. Dunn, Alan L. Ho, Eric J. Sherman, Nadeem Riaz, Nancy Y. Lee

This cohort study describes 5-year outcomes following a de-escalated 30-Gy elective nodal irradiation regimen during definitive concurrent chemoradiotherapy among patients with human papillomavirus–associated oropharyngeal carcinoma.

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