DOI: 10.1158/1078-0432.ccr-26-2090 ISSN: 1078-0432
Liquid Biopsy in Biliary Tract Cancer: When Tissue is Not Enough
Lewis Au, Jeanne TieAbstract
Circulating tumor DNA (ctDNA) profiling detects actionable genomic alterations in advanced biliary tract cancer faster (8 vs 27 days) and more often (90% vs 50%) than tissue, with high concordance. A recent retrospective study establishes clinical validity and a compelling access case for future prospective ctDNA-directed trials.