DOI: 10.1039/d6cp02431a ISSN: 1463-9076
Lipidomic adaptation and membrane physical changes underlie tamoxifen resistance in breast cancer: molecular dynamics simulation study
Elahe Hoseinnia, Fatemeh Ebrahimi Tarki, Mahboobeh Zarrabi, Zahra HajimahdiMulti-scale MD captures biophysical characteristics in cancer plasma membranes. CHL/SM enrichment condenses membranes and reduces fluidity. PMF profiles reveal CHL/SM-rich bilayers as energetic traps that severely restrict tamoxifen permeation.