DOI: 10.1039/d6ra05448j ISSN: 2046-2069
Lipid tail length dictates membrane disruption by carmofur analogs and reveals noncanonical modes of action
Chancie Chou, Arin Kasliwal, Lavernie Chen, Kathleen Hsu, Aarav Anand, Uday Srivastava, Sanika Vaidya, Felicia Leung, Eileen Yuyama, Ieva Chepurna, Mansha Gupta, Lucas Quan, Nolan Tsai, Kayla Huang, Olivia Kwok, Jenny Zhang, Audrey Tseng, Viet-Tran Gemma Do, Evelyn Du, Tapash Jay Sarkar, Akira Yamamoto, Joseph Laurienzo, Joseph Pazzi, Edward NjooEnabled by an optimized computer vision platform for large-scale image analysis, we demonstrate that lipidated carmofur analogs of varying alkyl length exhibit potent membrane-disrupting activity on giant unilamellar vesicles (GUVs).