Ligand‐Promoted Cu(I)‐Catalyzed Coupling of Aryl Bromides With NH ‐Heterocycles in Aqueous Micellar Conditions

A general micellar catalysis protocol has been developed for ligand‐assisted copper‐catalyzed Ullmann‐type C─N coupling reactions in water using commercially available surfactant TPGS‐750‐M. This sustainable and cost‐effective method demonstrates broad substrate scope, efficiently coupling diverse (aryl)heteroaryl bromides with privileged nitrogen heterocycles including indoles, pyrazoles, imidazoles, and benzimidazoles. Notably, >20 examples of heteroaryl bromides are accommodated with good functional group tolerance. The green methodology provides practical access to biologically important N ‐arylated azoles, including structurally challenging polyheteroatomic frameworks, thereby offering significant advantages for pharmaceutical applications.