Level IL-15 and IL-21 in Serum Patients Iraqi with Celiac Disease

Abstract

Celiac disease (CD) is an autoimmune intestinal illness brought on by gluten in people with certain genetic predispositions, also known as gluten-sensitive enteropathy. Interleukin (IL)-15 and IL-21 play an important role in the development of celiac disease. The study aims to assess the immunological parameters to identify immunological features that could be connected to Celiac disease. ELISA test kits are a measurement of the quantitative inflammatory ILs of serum levels. Statistical analysis was carried out using the softwar program Statistical Package for Social Science (SPSS) version 26. Independent-samples Mann–Whitney U test was used to assess the mean difference between two independent samples. Kolmogorov–Smirnov and Shapiro–Wilk tests were used to define the normal distribution of data. There was a statistically significant ( P = 0.001) increase in IL-15 serum levels between CD patients and a statistically significant ( P ≥ 0.001) increase in IL-21 serum levels. The results showed that IL-15 and IL-21 may be useful and practical indicators for differentiating celiac disease patients from healthy.