DOI: 10.18609/cgti.2026.108 ISSN: 2059-7800

Lessons from 30 years at the bench and bedside: the evolution of AAV gene therapy

Terence Flotte
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Abi Pinchbeck, Editor, Cell & Gene Therapy Insights, speaks with Terence Flotte, Elisabeth Chair for the Dean of Medicine and Executive Deputy Chancellor of UMass Chan Medical School, past President of the American Society of Gene and Cell Therapy, about the origins of AAV-based gene therapy, the evolution of the field over three decades, the remaining safety and dose challenges, expanding beyond rare disease, and emerging initiatives to improve global patient access.

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