Lean body mass is the independent and predominant anthropometric variable associated with incident atrioventricular block: a prospective population-based cohort study
H Chung, P Yang, H Bae, H Park, D Kim, H Yu, T Kim, J Uhm, J Sung, H Pak, B JoungAbstract
Background
There is limited information regarding the association between lean body mass and incident atrioventricular block.
Purpose
To evaluate the association between lean body mass and the risk of atrioventricular block.
Methods
370,415 participants from the UK Biobank cohort who underwent bioimpedance analysis with no history of atrioventricular block or cardiac implantable electronic devices were included in the analyses. The primary outcome was a composite of second- or third-degree atrioventricular block. Secondary outcomes included each component of the primary outcome and atrioventricular block-related pacemaker implantation.
Results
The mean age was 56.8 years, and 47.6% were men. During a median follow-up of 11.8 years, 1519 and 677 primary outcome events occurred in men and women, respectively. Lean body mass per 1 standard deviation increase (7.7 kg in men; 5.0 kg in women) was associated with a 15% (HR: 1.15, 95% CI: 1.09 to 1.21, P < 0.001) and 13% (HR: 1.13, 95% CI: 1.05 to 1.22, P = 0.001) higher risk of the primary outcome in men and women, respectively. These associations remained significant after adjusting for various anthropometric variables, including fat mass. A similar pattern was observed for all secondary outcomes. Higher lean body mass was associated with an increased prevalence of prolonged PQ interval in both sexes (P value for trend: <0.001 for all comparisons).
Conclusions
Higher lean body mass was associated with increased risk of the incident atrioventricular block in both men and women and was linked to a higher prevalence of prolonged PQ interval.Figure 1.