Outline
DOI: 10.1039/d6ra07137f ISSN: 2046-2069
LC-MS/MS-based metabolomics and PK/PD correlation analysis reveal the mechanism of hyperlipidemia treatment with Gastrodia elata fine powder
Weiwei Xie, Meijuan Liu, Jiajun Li, Yuqian Zhang, Jingpu Xu, Chenyuan Wang, Ye Yuan, Yiran Jin, Yingfeng Du, Deqiang LiMetabolomics links the lipid-lowering effects of Gastrodia elata fine powder in rats to amino acid and energy metabolism. Separate gastrodin pharmacokinetic/pharmacodynamic modelling reveals metabolic responses that lag behind drug exposure.
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