Labeling Peptides with Radioiodine: An Overview of Traditional and Emerging Techniques

This review focuses on the synthetic methodologies for radioiodinating peptides, a crucial process for developing effective radiopharmaceuticals used in diagnostics and therapeutics. We explore direct and indirect radioiodination methods, including mechanisms, reaction conditions, and purification strategies. The focus is on the chemical approaches that enable radioiodine incorporation into peptide structures, considering the challenges of maintaining peptide integrity and biological activity. This article is intended as a detailed resource for understanding traditional approaches and recent chemical developments in radioiodination.