K₂S₂O₈‐Promoted Direct Chalcogenation and Nitrosation at C‐3 Position of Imidazo[1,2‐a]pyridines Under Mild Conditions

Abstract

K₂S₂O₈‐promoted an efficient method for regioselective chalcogenation (S and Se), and nitrosation of imidazo[1,2‐a]pyridines at C‐3 position was achieved using diorganoyl dichalcogenides, thiols, and sodium nitrite under metal‐free conditions. This approach provides direct access to structurally diverse chalcogenated and nitroso imidazopyridines through sp² C─H functionalization in good to excellent yield by using K₂S₂O₈ as an oxidant. The operational simplicity, good regioselectivity, high atom economy, and use of ambient conditions are the attractive features of the reaction.