DOI: 10.1039/d6cb00196c ISSN: 2633-0679
Kinase cascades: emerging design principles and guidelines
Ruth Nussinov, Clil Regev, Hyunbum JangActivation energy barriers indicate that the Raf–MEK–ERK pathway operates via a sequential kinase cascade. Conversely, the PI3K, PDK, AKT, and mTOR pathway relies on lipid second messengers and multiple phosphorylation steps.