Ketoprofen-Loaded into FSM-g-poly(NVP) Pellets as a Model Drug: Formulation, Development, and Evaluation
Kavita Bahmani, Samiksha grewal, Shweta Sehrawat, Manisha Kumari, Nisham Rani, Shiva Tushir, Neelam Sihag, Sunita DeviIntroduction:
Flaxseed mucilage is a polysaccharide mucilage that is extracted from dried, fully grown flax or linseed seeds. There are two primary types of flax seeds: brown flax seeds and golden or yellow flax seeds, often called golden linseeds. The aim of the present study is to graft copolymerization of flaxseed mucilage using N-vinyl-2-pyrrolidone (NVP) and Ammonium Persulfate (APS) by employing microwave power and to prepare and evaluate mucoadhesive pellets utilizing Flaxseed Mucilage (FSM) and NVP-grafting-FSM.
Methods:
FSM and FSM-g-poly (NVP) were assessed for mucoadhesive applications by formulating the buccal pellets using ketoprofen as the model drug. The optimization of graft copolymerized FSM was prepared using a two-factor, three-level central composite design. The optimized batch suggested by the design expert was characterized by Fourier Transformation Infrared Analysis (FTIR), Differential Scanning Calorimetry analysis (DSC), Scanning Electron Microscopy Analysis (SEM), and X-Ray Diffraction Analysis (XRD).
Results:
The SEM images of FSM and FSM-g-poly (NVP) revealed that the flaxseed was polyhedral in shape with a smooth flaky surface, and the grafted sample was cubic in shape with a rough granular surface. Thus, the result of the SEM analysis confirmed the formation of the graft copolymer.
Discussion:
On comparative evaluation of ketoprofen-loaded FSM-g-poly (NVP) with the FSM pellets, the pellets of FSM-g-poly (NVP) showed higher bioadhesion and prolonged release of drug in 12 hours.
Conclusion:
In conclusion, FSM -g- poly (NVP) can be explored as bio adhesion material for drug delivery.