DOI: 10.1111/1756-185x.70939 ISSN: 1756-1841
Juvenile Dermatomyositis With Dual Myositis‐Specific Antibodies and Rapidly Progressive Interstitial Lung Disease: A Pediatric Case Report
Anwesha Ghoshal, Shrestha Banerjee, Satyabrata Roy Chowdhoury, Suprit BasuPractitioner Points
This case provides evidence that dual positivity for myositis‐specific antibodies, specifically anti‐MDA5 and anti‐OJ, can occur in pediatric JDM, challenging the traditional concept of mutual exclusivity. It highlights the potential additive impact of myositis‐associated anti‐Ro52 antibodies in driving severe ILD and high mortality. The report emphasizes the importance of early imaging and inflammatory marker monitoring, particularly ferritin, for high‐risk stratification, and underscores the aggressive clinical course and high mortality associated with RP‐ILD requiring intensive care support.