DOI: 10.1182/blood.2026033425 ISSN: 0006-4971
JAK3 regulates PIP5K expression, promotes PIP2 generation and Ca2+ driven platelet activation in arterial thrombosis
Patrick Münzer, Ferdinand Kollotzek, Mailin-Christin Manke, Betül Findik, Kristina Mott, Melina Fischer, Gundula D Lingens, Monika Zdanyte, Frederic Stein, Sascha Geue, Britta Walker, Meinrad Gawaz, Tobias Geisler, Dominik Rath, Robert Ahrends, Michael Lämmerhofer, Harald Schulze, Julia Skokowa, Oliver BorstPhospholipase C (PLC)-evoked rising intracellular Ca2+-levels are a prerequisite for platelet activation with subsequent thrombosis. The protein-tyrosine kinase Janus kinase 3 (JAK3) regulates phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-levels in platelets, thus significantly mediating activation-dependent platelet function and arterial thrombosis.