DOI: 10.1021/acs.orglett.6c02295 ISSN: 1523-7060
Iron-Catalyzed Direct Synthesis of Amides from Alcohols
Arijit Singha Mohapatra, Santana Chakraborty, Subhankar Khanra, Nanda D. PaulAbstract
Herein, we report an iron-catalyzed, one-pot, direct synthesis of amides via dehydrogenative amidation of alcohols using methoxyamine hydrochloride as a nitrogen source. Enabled by a well-defined Fe(II) catalyst of a redox-active azo–phenanthroline ligand, the reaction proceeds via the cooperative participation of iron and the ligand, producing a broad spectrum of amides, including (hetero)aromatic and aliphatic amides, and complex bioactive amide molecules in good isolated yields.