PDE8B rs4704397 Modifies the Association Between Iodine Status and Serum TSH in Pregnant Women
Cui Yao, Yongze Li, Chenyan Li, Weiwei Wang, Xiaochen Xie, Chenling Fan, Weiping Teng, Zhongyan Shan, Jinyuan MaoBackground:
Maternal thyroid function is essential for a healthy pregnancy, and elevated thyrotropin (TSH) is the hallmark of subclinical hypothyroidism (SCH). Previous studies have shown that both genetic factors, particularly the
Methods:
We performed a retrospective analysis of prospectively collected data from the subclinical hypothyroid in early pregnancy (SHEP) prospective cohort, using a nested case-control design. The analysis included 728 pregnant women with SCH and 968 age- and body mass index-matched euthyroid controls. Participants were genotyped for
Results:
The distribution of the AA genotype did not differ between case and control groups. In the overall population, the AA genotype accounted for 70% of participants. RCS analyses showed a positive linear association between UIC/Cr and serum TSH concentrations in both the overall population and individuals with the AA genotype, but not in those with the GA + GG genotypes. A nonlinear inverse association between UIC/Cr and fT4 levels was observed across all genotypes. Among individuals with the AA genotype, each standard deviation increase in UIC/Cr was associated with higher serum TSH levels (adjusted β = 0.16, confidence interval [CI]: 0.08–0.24) and an increased risk of SCH (OR = 1.22, CI: 1.08–1.39), but not among those with the GA + GG genotypes (
Conclusions:
Higher iodine status was associated with higher TSH levels and an increased risk of SCH only among pregnant women with the