Para ‐Selective C─H Amination of Benzenepropanamides via Photocatalytic N ‐Centered Radical‐Mediated Dearomatization
Di‐Jing Luo, Dan‐Na Chen, Li‐Ning Chen, Lu‐Lu Qin, Yu Lv, Zhi‐Peng Ye, Yu Zheng, Shu‐Hui Li, Peng‐Ju XiaWe report a photocatalytic strategy for constructing para ‐aminobenzenepropanamide scaffolds. This method employs oxime‐ester‐based diamination reagents as dual‐radical precursors to generate imino and amidyl radicals. The key step involves N ‐centered radical‐mediated intramolecular dearomatization, forming the cyclohexadienyl radical (CHDR) intermediate. This protocol features mild reaction conditions and broad functional group tolerance. Furthermore, this method achieves selectivity that is not affected by the stereochemical or electronic properties of the benzene ring, thereby enabling the efficient synthesis of 4‐aminobenzoylamide.