Intestinal Fatty Acid-binding Protein in Patients with Psoriasis: A Marker of Impaired Intestinal Permeability Barrier and its Relation to Demographic Data and Clinical Characteristics
Ayman Mahran, Amal Hosni, Ahmed A. A. Mageed- General Medicine
Abstract
Background:
Alterations of intestinal microbiota may play a role in the pathogenesis of psoriasis. Dysbiosis may cause disruption of the intestinal barrier, which contributes to immune activation by translocation of microbial antigens and metabolites. Intestinal fatty acid-binding protein (I-FABP) serves as a biomarker of enterocyte damage.
Purpose:
The aim of this study was to investigate serum concentration of I-FABP in patients with psoriasis.
Methods:
A cross-sectional hospital-based study on fifty psoriatic patients and thirty-five age and sex-matched healthy volunteers as a control group were enrolled in the study, serum I-FABP concentration was measured using an enzyme-linked immunosorbent assay.
Results:
Concentration of serum I-FABP was higher in patients compared to controls (
Conclusion:
I-FABP, a biomarker for gut permeability, is increased in psoriasis and correlates with disease duration and age. Further investigations are needed to determine whether reinforcing intestinal barrier may be a new therapeutic target in psoriasis.