Inter-Relationship between Creatinine Phosphokinase and Ejection Fraction

It is interesting to examine the associations between serum creatinine phosphokinase (CPK) level and some of the cardiac riskfactors such as blood pressure, heart rate, ejection fraction (EFT), etc. in heart patients. The article aims to examine the interrelationshipbetween CPK level and EFT in heart patients.MethodsThe inter-relationship between CPK level and EFT in heart patients is examined herein using the probabilistic model of CPK onEFT along with the other explanatory variables and factors, and conversely. The CPK level or EFT model is derived by applyingjoint generalized linear models (JGLMs).ResultsThe CPK level mean model shows that mean CPK is directly related to EFT (p=0.04) and AGE (p=0.03), while it is inverselyrelated to their joint interaction effect of AGE and EFT, i.e., AGE*EFT (p=0.01). The mean CPK is inversely related to serumcreatinine (SCT) (p<0.01), while it is directly related to the EFT (p=0.04), and their joint interaction effect is EFT*SCT (p<0.01).From the EFT mean model, it is derived that EFT is directly related to CPK (p=0.01) and AGE (p<0.01), while it is inverselypartially related to their joint interaction effect, AGE*CPK (p=0.12). Mean EFT is indifferent to SCT (p=0.39), while it is directlyrelated to the joint interaction effect of CPK (p=0.01) and SCT, i.e., CPK*SCT (p<0.01). Mean EFT is directly related to serumsodium (SNa) (p<0.01) and CPK (p=0.01), while it is inversely related to the joint interaction effect of CPK*SNa (p=0.01). Fromthe variance model of EFT, the variance of EFT is inversely related to CPK (p=0.04).ConclusionBased on the derived CPK level and EFT models, it is derived that CPK and EFT are interrelated with each other through AGE,SCT, SNa, and some interaction effects. Heart patients and practitioners should care about the interrelationship of CPK levelsand EFT for better treatment.