Integrating Lifestyle, Mechanistic Therapeutics, and Computational Approaches in Cancer: Highlights from the Irish Association for Cancer Research Annual Conference 2025

The Irish Association for Cancer Research (IACR) Annual Conference 2025, held in Belfast, showcased cutting-edge developments across the cancer research landscape. This report summarizes key presentations, highlighting innovations in drug delivery, exercise interventions, artificial intelligence and computational biology, cancer stem cell plasticity, and translational research approaches. The meeting emphasised mechanistically informed strategies, multi-modal therapies, and the integration of patient-relevant models to improve therapeutic outcomes. The sessions collectively underscored the importance of combining biological, chemical, and physical approaches, as well as emerging tools in precision oncology, to address therapeutic resistance and enhance patient care.