DOI: 10.1039/d6lc00377j ISSN: 1473-0197
Integrated “gut–liver”-on-a-chip (iGLoC): an immune-competent and metabolically active microphysiological model of the gut–liver axis for drug screening, validated by abemaciclib pharmacokinetics, hepatotoxicity, and drug–drug interaction studies
Sultan K. AlShmmari, Dana Cialla-May, Jürgen Popp, Mohammed Zourob, Qasem RamadaniGLoC: immune-competent in vitro model recapitulates gut–liver PK of abemaciclib, generating clinically relevant metabolites, DDIs, and hepatotoxicity signatures for preclinical screening of small-molecule cancer therapeutics.