DOI: 10.1039/d6ra03459d ISSN: 2046-2069
Integrated design, synthesis, biological evaluation, and computational mechanistic insights of novel benzanilide derivatives as VEGFR-2 targeted anticancer agents
Ahmed M. Metwaly, Walid E. Elgammal, Ibrahim H. Eissa, Hazem A. Mahdy, Mohammed S. Taghour, Aisha A. Alsfouk, Fatma G. Amin, Dalal Z. Husein, Eslam B. Elkaeed, Hazem ElkadyA novel benzanilide-based derivative, 7e, was designed, synthesized, and identified as a potent VEGFR-2 inhibitor with promising anticancer activity supported by biological and computational studies.