Integrated Colorimetric/Fluorescence Nanozyme Dual‐Signal Probe for Simultaneous Detection and Degradation of Organophosphorus Nerve Agents

ABSTRACT

Organophosphorus nerve agents pose grave risks to human health and ecology, creating an urgent demand for high‐performance detection and remediation techniques. This work fabricates an all‐in‐one sensing‐degradation platform with UiO‐67@AuNCs/MnO ₂ nanozyme and AChE biorecognition element, where MnO ₂ acts as a reversible switch to regulate fluorescence and oxidase‐like activity. The system delivers inverse dual optical signals for self‐verification, greatly boosting detection precision. Tested on real sarin and soman, its colorimetric and fluorescent LODs reach 10 ⁻³ –10 ⁻⁴ ng·mL ⁻¹ , 2–7 orders of magnitude lower than most reported sensors. Benefiting from UiO‐67's porous structure, the composite adsorbs nerve agents and achieves over 80% sarin and 70% soman degradation within 6 h at room temperature without extra energy or reagents, eliminating secondary contamination risks. Capable of universal screening of organophosphorus toxins, this multifunctional platform holds great value for military chemical defense and civilian environmental monitoring, offering a simple integrated strategy for simultaneous pollutant detection and detoxification.