DOI: 10.1182/blood.2026034384 ISSN: 0006-4971

Initial fixed low-versus moderate-dose hydroxyurea assignment in the long-term follow-up of the SPRINT cohort

Shamsu Muhammad Iguda, Shehu U. Abdullahi, Ibrahim Musa Idris, Abdulkadir Halifa Yusuf, Surayya Murtala Sunusi, Khadijah A Bulama, Hauwau Aminu Inuwa, Mark J Rodeghier, Michael R DeBaun
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In this pragmatic long-term follow-up of the SPRINT randomized trial cohort, rates of recurrent stroke and all-cause mortality did not differ significantly by an initial fixed low- versus moderate-dose of hydroxyurea over 4.9 years, with events clustering in the first year.

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