DOI: 10.1126/science.1211485 ISSN:
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
Dimitrios Anastasiou, George Poulogiannis, John M. Asara, Matthew B. Boxer, Jian-kang Jiang, Min Shen, Gary Bellinger, Atsuo T. Sasaki, Jason W. Locasale, Douglas S. Auld, Craig J. Thomas, Matthew G. Vander Heiden, Lewis C. Cantley- Multidisciplinary
The glycolytic metabolism of cancers differs from normal tissues, allowing tumor cells to survive under oxidative stress.