Informatics at the Frontier of Cancer Research
Kathleen Noller, Taxiarchis Botsis, Pablo G. Camara, Lauren Ciotti, Lee AD. Cooper, Jeremy Goecks, Malachi Griffith, Brian J. Haas, Trey Ideker, Rachel Karchin, Despina Kontos, Jiaying Lai, Daniel Marcus, Clifford A. Meyer, Kristen Naegle, Sarthak Pati, Bjoern Peters, Dexter Pratt, Benjamin J. Raphael, Michael Reich, Guergana K. Savova, Carrie Wright, Elana J. Fertig, Spyridon BakasAbstract
Digitized healthcare data, high-throughput profiling technologies, and data repositories have facilitated the emergence of a new era of cancer research. Each data stream requires specialized analysis methods for interpretation. The data-driven era of cancer research requires the development, enhancement, and sustainment of informatics technology software infrastructure, including fundamental methodology development in artificial intelligence and data science. We review current and emerging informatics technology developments for cancer research and discovery, spanning molecular and cellular characterization, image analysis, informatics, and therapeutics. Summarizing the diverse methods and applications of informatics throughout cancer research identifies themes and emerging areas for the next generation of cancer research.