DOI: 10.54005/geneltip.1737233 ISSN: 2602-3741

Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis

Ali Can Çiçek, Mehmet Fatih Aksay
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Aim: Hip fractures cause high mortality in older adults. This study examined the success of inflammatory markers detected at hospital admission in predicting long-term survival outcomes in elderly patients undergoing hip fracture surgery.Materials and Methods: The retrospective cohort study analyzed 90 patients aged 65 years and older who received hip fracture surgery from 2016 through 2020. The patients were separated into two groups based on their one-year follow-up status: survivors (n=78) and deaths (n=12). The admission measurements included Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and C-reactive protein/albumin ratio (CAR). The ROC analysis determined the optimal cut-off values. The Cox regression analysis evaluated the risk factors for mortality.Results: One-year mortality was 13.3%. In ROC analysis, the area under the curve was 0.78 for CAR, 0.72 for NLR and 0.68 for MLR. The optimal cut-off value for CAR was 1.36 (sensitivity 83%, specificity 71%). In multivariate analysis, CAR≥1.36 (HR=2.18; p=0.006), advanced age (HR=1.06; p=0.003) and high comorbidity index (HR=1.25; p=0.032) were independent predictors of mortality.Conclusions: On admission, CAR has a higher predictive value than other inflammatory markers in predicting mortality in hip fracture patients. This simple and easily calculated parameter can be used in risk assessment.

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