DOI: 10.1039/d5dt03030g ISSN: 1477-9226
Improving the anticancer efficacy of azole–platinum(
ii
) complexes through a Pluronic® micelle formulation strategy
Adriana Kaszuba, Jerzy Sitkowski, Tadeusz Muzioł, Agnieszka Tafelska-Kaczmarek, Karolina Pokrzywka, Łukasz Kaźmierski, Ilona Gurgul, Małgorzata Maj, Janusz M. Dąbrowski, Iwona Łakomska A series of novel azole–platinum(
ii
) complexes was synthesized and investigated for anticancer activity. Among them, a triazole-based complex exhibited promising cytotoxicity against lung and bladder cancer cells, which was dramatically enhanced after encapsulation in polymeric micelles.