Improving Atrial Fibrillation or Flutter Detection and Management by Smartphone-Based Photoplethysmography Rhythm Monitoring Following Cardiac Surgery: A Pragmatic Randomized Trial
Henri Gruwez, Nicolas De Melio, Paulien Vermunicht, Leen Van Langenhoven, Lien Desteghe, Marie Lamberigts, Dieter Nuyens, Hugo Van Herendael, Inez Rodrigus, Christiaan Van Kerrebroeck, Pieter Vandervoort, Hein Heidbuchel, Laurent Pison, Filip Rega, Peter HaemersAbstract
Background and Aims
Atrial fibrillation (AF) or atrial flutter (AFL) after cardiac surgery are common and associated with adverse outcomes. The increased risk related to AF or AFL may extend beyond discharge. This study aims to determine whether photoplethysmography (PPG)-based smartphone monitoring to detect AF or AFL after hospital discharge following cardiac surgery improves AF management.
Methods
The intervention group performed one-minute rhythm checks three times daily using a smartphone-based PPG application during six weeks after hospitalization for cardiac surgery. The primary outcome involved AF management interventions by independent physicians, including initiation of oral anticoagulation (OAC), direct cardioversion and up-titration or initiation of antiarrhythmic drugs.
Results
The study included 450 patients (mean [SD] age, 64.1 [9.2] years; 96 women [21.3%]; 130 patients with AF history [28.9%]; median [IQR] CHA2DS2-VASc score, 2 [1-3]), of whom 238 were randomized to PPG-based monitoring and 212 to usual care. AF/AFL was detected with PPG or electrocardiography in 44 patients (18.5%) in the monitoring group and 4 patients (1.9%) in the usual care group (OR 11.8; 95%CI, 4.2-33.3; P<.001), these were new detections in respectively 22 patients (9.2%) and 1 patient (0.5%) (OR 21.3; 95%CI, 2.9-166.7; P=.003). AF management interventions occurred in 24 patients (10.1%) in the monitoring group compared to 5 patients (2.4%) in the usual care group (odds ratio [OR]), 5.1; 95%CI, 1.8-14.4; P=.002).
Conclusions
In unselected patients discharged home following cardiac surgery, PPG-based smartphone monitoring revealed significantly more AF/AFL which led to significantly more optimization of AF management.