Impact of targeted blood pressure management versus standard care amongst high-risk patients undergoing major abdominal surgeries: A pilot study
Madhubala Venkatesan, Lakshmi Kumar, Sudarsana P. Nagarajan, Ramya Anantharaman, Renjitha BhaskaranABSTRACT
Background and Aims:
Targeting blood pressures closer to the patient’s normal could result in a reduction in post-operative morbidity amongst high-risk patients undergoing abdominal surgery. The study primarily evaluated the impact of targeted mean arterial pressure (MAP) (20% baseline) versus standard care on organ dysfunction. The secondary outcomes assessed were length of intensive care unit (ICU) and hospital stay along with all-cause mortality.
Methods:
Patients aged 45 years and above with diabetes mellitus, coronary artery, peripheral or cerebral vascular disease (
Results:
Post-operative troponins, creatinine, platelet count, international normalised ratio, and cognitive and respiratory outcomes were comparable. The time-weighted average of MAP <65 mm Hg was 0.017 ± 0.127 mm Hg in Group T and 0.057 ± 0.295 mm Hg in Group S,
Conclusion:
Targeted blood pressure management in high-risk patients undergoing abdominal surgery did not result in differences in post-operative outcomes in comparison to the standard care. The lengths of ICU and hospital stay were longer in Group T, probably due to the higher risk profile of patients in this group.