Impact of melatonin on the healing of induced tongue wound in albino rats exposed to social isolation
Olfat M. Gaballah, Hasan J. Sarahna, Gihan S. Hassan, Reda G. SalehIntroduction
The pineal gland hormone melatonin is a widely recognized neuroendocrine hormone. Beyond its anti-inflammatory, antioxidant, and immunomodulator role.
Objectives
This study examines the impact of social isolation on the healing of tongue wounds in albino rats and explores whether oral melatonin can counteract the negative effects of isolation stress on wound recovery.
Patients and methods
The study included 60 adult male albino rats divided equally into three groups. Group I (induced wound group-control group), group II (stress exposed group and induced wound group), and group III (stress exposed, induced wound and melatonin-treated group). The investigation included a light microscope, transmission electron microscopic examination, and histomorphometric analysis of the proliferating cell nuclear antigen immunostaining.
Results
This study revealed that melatonin enhanced normal wound healing by influencing and modulating key biological processes essential to the healing response, including inflammation, angiogenesis, and collagen synthesis.
Conclusion
Melatonin treatment showed potential benefits for oral wound healing, as it accelerated the healing process and improved the quality of the healing tissue. Oral administration of melatonin could offer a promising therapeutic approach for treating oral and tongue wounds and ulcers, opening new possibilities for future wound repair therapies.