Impact of hypertrophic cardiomyopathy on work productivity and activity impairment in patients with HCM: analysis of a real-world cross-sectional survey
P Gebrehiwet, J Jackson, L Hancock, S Barlow, L Lebrocq, E Green, M Butzner, S ShreayAbstract
Objectives
To evaluate the impact of hypertrophic cardiomyopathy (HCM) on work productivity and activity impairment in patients with HCM.
Methods
Data for patients with HCM were analyzed from the Adelphi HCM Disease Specific Programme™, a real-world cross-sectional survey with retrospective data collection in Italy, Spain, and the United States. Patients’ productivity and impairment due to HCM was collected using the work productivity and activity impairment questionnaire (WPAI), and reported as mean (%) impairment per domain. Higher mean (%) indicated less productivity and greater impairment. Results were stratified by HCM type (obstructive HCM [oHCM] and non-obstructive HCM [nHCM]) and compared using t-tests.
Results
WPAI activity and work impairment data were available for 273 and 101 patients with HCM, respectively. Patient characteristics are presented in Table 1. Of those, 43.94% were working full time, 33.71 % were retired, 6.82% working part time, 6.06% were homemakers, 5.68% were unemployed and <5% were either students or on long term sick leave (Table 1). Full time and part-time employed HCM patients, reported that 15.35% of their time at work was impaired due to HCM in the past 7 days and on average, that they missed 1.63% of work time (Table 2). Additionally, employed patients reported experiencing 16.11% overall work impairment due to HCM. All HCM patients reported on average, 26.63% of activity impairment due to HCM (Table 2). Work impairment did not differ significantly by HCM type. Patients with oHCM and nHCM reported 17.83% and 10.00% impairment whilst working (p=0.5485), 1.88% and 1.09% work time missed (p=0.0619) and 18.74% and 10.43% overall work impairment (p=0.0622), respectively (Table 2). Patients with oHCM reported greater activity impairment when compared to patients with nHCM (30.16% vs 19.20% respectively, p=0.0003) (Table 2).
Conclusions
HCM imposes a significant burden on work productivity and daily activities, with over a quarter of regular daily activity of patients being impaired due to HCM. This burden is consistent across HCM subtypes, though activity limitations are more pronounced in patients with oHCM. There is a clear need for effective treatments that improve functional capacity and productivity. Future research should assess how these impairments contribute to healthcare and societal costs, and how improved management can help reduce the broader economic impact of HCM.For image description, please refer to the figure legend and surrounding text.For image description, please refer to the figure legend and surrounding text.