Impact of Hemophilia on Lipid Profile in Children and Adolescents
Ali Khazaal Jumaa, Qutaiba Muslim Dawood, Mohammed Ahmed Al-AnssariAbstract
Background:
Chronic bleeding disorders known as hemophilia type A and hemophilia type B are brought on by insufficient clotting factors VIII and IX, respectively. Hemophiliacs may bleed sporadically or from small wounds, and the severity varies. The replacement of the absent clotting factor is often part of the treatment.
Objectives:
This study aimed to learn more about the clinical effects of lipid profile alterations in people with hemophilia.
Materials and Methods:
This is a case–control study of 35 healthy people and 32 people with hemophilia. This research was conducted at Basrah Haematology Centre from October 2022 to March 2023. All congenital hemophilia type A and hemophilia type B individuals were included in this study. A hemophilia patient’s data includes exercise, smoking, severity, treatment, complaint, symptoms, and work. In both groups, total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), and body mass index (BMI) are reported in this study.
Results:
Hemophilia patients have a mean age of 30.12 ± 9.2 months and a hemoglobin A1c (HbA1c) of 5.1 ± 0.44, with 34.4% exhibiting poor to moderate exercise and 59.4% smoking. While they have lower HDL levels than in normal individuals, there are no significant differences in LDL, TC, TG, and BMI. Hemophiliacs show varied lipid profiles and HbA1c levels, but there is no significant correlation between HbA1c and the lipid profile.
Conclusion:
High prevalence of HDL in hemophiliac patients compared with controls, with large HDL mean differences; lower HDL than in normal persons. TG decreases, and LDL and TG rise in individuals with hemophilia, although these three metrics do not differ between hemophilia and normal people. Therefore, hemophilia patients have a greater dyslipidemia rate than controls.