Impact of Dual Positron Emission Tomography Brain Imaging with 18F-FDOPA and 18F-FDG in the Diagnostic Approach to Non-Neurodegenerative Parkinsonism
Francisco Rubén Romero Castellanos, Fabio Andrés Sinisterra Solís, Emilly Alejandra Cortés Mancera, Nora Estella Kerik RotenbergAbstract
Metronidazole is a widely prescribed antibiotic used for treating bacterial and protozoal infections. Neurological complications from metronidazole are rare, but they have been associated with several syndromes, including cerebellar syndrome, encephalopathy, seizures, autonomic neuropathy, optic neuropathy, and peripheral neuropathy.
We present the case of a 25-year-old male patient who had a recurrent amoebic liver abscess, received long-term intravenous and oral treatment with metronidazole, and developed cerebellar syndrome and parkinsonism.
Electroencephalogram, computed tomography scan, and magnetic resonance imaging of the brain, along with various laboratory tests, revealed no abnormalities.
The molecular imaging service performed a dual positron emission tomography imaging with FDG and FDOPA, ruling out neurodegenerative parkinsonism and suggesting a possible pharmacological cause.