In vitro activity of tebipenem and comparator agents against bacterial pathogens isolated from patients with cancer
Bahgat Gerges, Joel Rosenblatt, Samuel A Shellburne, Anne-Marie Chaftari, Ray Hachem, Issam Raad- Microbiology (medical)
- Infectious Diseases
- Immunology and Allergy
- Microbiology
- Immunology
Abstract
Background
Tebipenem is a broad-spectrum orally administered carbapenem antibiotic that could be an alternative to IV carbapenems. The current study evaluated in vitro activity of tebipenem against bacterial isolates recovered from patients with cancer.
Methods
A total of 611 bacterial pathogens recently isolated from patients with cancer were tested for susceptibility to tebipenem and comparators. CLSI-approved broth microdilution methods were used. MIC50, MIC90, MIC range and percentage susceptibility calculations were made using FDA breakpoints when available.
Results
Tebipenem had a low MIC90 for most Gram-positive and Enterobacterales isolates. Tebipenem MIC90 ranged from 0.06 to 0.25 mg/L for all tested Enterobacterales.
Conclusions
Oral tebipenem has promising activity against clinically significant bacterial pathogens isolated from patients with cancer. Further clinical evaluation of tebipenem for the treatment of bacterial infections in patients with cancer is warranted.