DOI: 10.1039/d6ra06850b ISSN: 2046-2069
Identification of novel PKR inhibitory chemotypes via integrated molecular modelling and machine learning
Ghyda'a Shakhatreh, Mutasem. O. Taha, Safa DaoudInterferon-inducible RNA-dependent protein kinase (PKR) is an emerging therapeutic target involved in cancer, neurodegeneration, and inflammatory disorders; however, the discovery of potent and structurally diverse PKR inhibitors remains limited.