Identification of MKI67, TPR and TCHH Mutations as Prognostic Biomarkers for Patients with Defective Mismatch Repair Colon Cancer Stage II/III
Jingfang Lv, Wenbin Li, Xintong Wang, Lei Guo, Dongliang Wang, Yiran Zhang, Jun Yu, Tianli Chen, Beifang Niu, Xishan Wang, Zheng Liu- Gastroenterology
- General Medicine
BACKGROUND:
Stage II/III disease is the most predominant form of colorectal cancer, accounting for approximately 70% of cases. Further, approximately 15%-20% of patients with stage II/III disease have deficient mismatch repair or microsatellite instability-high colorectal cancer. However, there are no identified significant prognostic biomarkers for this disease.
OBJECTIVE:
This study aimed to identify prognostic markers for patients with deficient mismatch repair/microsatellite instability-high colon cancer stage II/III.
DESIGN:
Retrospective study design.
SETTING:
The study was conducted at a high-volume colorectal center, the Cancer Hospital, Chinese Academy of Medical Sciences.
PATIENTS:
Patients diagnosed with stage II-III deficient mismatch repair/microsatellite instability-high colon cancer who underwent curative surgery at the Cancer Hospital Chinese Academy of Medical Sciences between July 2015 and November 2018.
MAIN OUTCOME MEASURES:
The primary outcome measure was the influence of differentially mutated genes on progression-free survival.
RESULTS:
The retrospective deficient mismatch repair/microsatellite instability-high cohort and The Cancer Genome Atlas-microsatellite instability-high cohort involved 32 and 45 patients, respectively. The deficient mismatch repair/microsatellite instability-high patients had higher mutational frequencies of
LIMITATIONS:
This study was limited by its retrospective nature.
CONCLUSIONS: