ID #63 Pediatric Meningiomas, case series.
Wangky CarrascoAbstract
Background
Meningiomas are rare in pediatrics, accounting for 1-2% of pediatric CNS tumours. In addition, they exhibit a somewhat different clinical spectrum and pathological findings compared with adult cases.
Methods
We identify, in our tertiary center database, 5 cases from 2006-2021 that underwent surgical resection at Hospital Civil Juan I. Menchaca, Guadalajara, Mexico.
Results
The case series included four girls and one boy, with a mean age of 9.8 years ( range 1 -15 yr.). The most common symptoms were seizures, headache and ocular manifestations( blurry vision, diplopia and strabismus) with onset one-year before diagnosis, of whom two had raised intracranial pressure at the time of diagnosis. Brain MRI revealed an extensive range ( 31x47mm, 88x19mm, 45x30mm, 50x50mm of extra-axial masses, of which four were intracranial (parietal, parieto-occipital and frontoparietal regions) and one intra and extracranial( petroclival region and pterygopalatine fossa, respectively). The histopathological features were three transitional, one atypical and one fibrous. Three patients underwent complete resection with no recurrence during follow-up, and two patients with incomplete resection received radiotherapy.
Conclusions
Pediatric meningiomas usually have larger sizes and unusual localizations. Even though we were limited in terms of molecular diagnosis, we infer that they likely represented low grades, given the excellent treatment response. Future studies could explore specific treatment responses depending on molecular classification.