DOI: 10.1148/ryct.250295 ISSN: 2638-6135

Hyperpolarized Xenon 129 MRI to Evaluate Regional Gas-Exchange Abnormalities in Cystic Fibrosis Lung Disease

Stephanie A. Soderlund, Bilal I. Masokano, Matthew M. Willmering, Abdullah S. Bdaiwi, Riaz Hussain, Elizabeth L. Kramer, Laura L. Walkup, Zackary I. Cleveland

Hyperpolarized xenon 129 MRI revealed gas-exchange abnormalities in participants with cystic fibrosis compared with control participants; these abnormalities were not correlated with spirometry but persisted despite cystic fibrosis transmembrane conductance regulator modulator therapy.

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